Basic Information
VIS ID
TVIS10017248
Fusion event
HBV-LOC105379376 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2276
End
2369
Integrated sequence
GATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCT
Host Sequence
Chromosome
chr8
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
36838914/36981396 (Hg38)
End
36839016/36981498 (Hg38)
Location type
Intronic
Target gene
LOC105379376
Nearest miRNA
hsa-mir-124-1/Upstream/7024048; hsa-mir-10400/Downstream/4289550;
Nearest TSS
ENST00000518652/Upstream/52491; ENST00000517897/Downstream/87920;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1744803, chr8-CpG: 351/Downstream/712928
Upstream sequence
ACTTGGGTTGGTATCTGTGGGAGTTATGTATATGCTTCCAAAAGAGGCCAAATTCTCACAGGATATCAAAATAGCCTAGTGAGATAGTATCAGCAATGGG
Downstream sequence
TTTATTCCTGCAGAAACTCAGAAGAGGGCAAGGTGGCTGCAAGTTCCACCTAGAAGTGTCAGCAGGCCTGAACTCGCCTTCCTCCTGTCCTCTCCTCTGA
Target sequence
AATGCGTATGTGTTGTGTAGGGGAACTATTCTTTAGGGGGAAAACCCAGTAATTGGCAGTATGCTATTATTATAATTAAAAGCCTCGTTAACTGGAACAAAG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate