Basic Information
VIS ID
TVIS10017250
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1705
End
1797
Integrated sequence
TACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
11689/11689 (Hg38)
End
11784/11784 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Downstream/1051112;
Nearest TSS
ENST00000502646/Downstream/80367;
Nearest CpG islands
None/Target, None/Upstream, chr5-CpG: 87/Downstream/38906
Upstream sequence
GGACGGCGCCTCACTCACCCTACACGTGACAGGGACACCCGGGGACGGCGCCTCACTCACCCTGCACGTGACAGGGACACGCGGGGACGGCGCCTCACTC
Downstream sequence
taacccctaaccctaaccctaaaccctaaccctgaacccgaaccctgacccctgacccctgaccccgaccccgaccccgaccccgaccctgaccctaTGC
Target sequence
accctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaacccc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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