Fusion event
HBV-chr4 integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
GTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTA
End
49104895/49102878 (Hg38)
Nearest miRNA
hsa-mir-12113/Upstream/1450064; hsa-mir-1243/Downstream/3609804;
Upstream sequence
TGCCTCCTCATATTGTATAACTGGCTATATCAGACAGGTGTGTTTCTTTTCATACATTTCTTCATATTTATATCATTATAGATAAAAATATATTCAAATT
Downstream sequence
cattccattccattccactcgtgttgattcccttccattccattccattccattccactccattccacttgggttgattccattccgttcctttccattt
Target sequence
ccattccactccactcgggttgattccattccattccattccattccattccattccattccattccattg
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.