Basic Information
VIS ID
TVIS10017255
Fusion event
HBV-ANKRD18B integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
534
End
627
Integrated sequence
ACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTT
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
33572432/33572434 (Hg38)
End
33572519/33572521 (Hg38)
Location type
Intron
Target gene
ANKRD18B
Nearest miRNA
hsa-mir-101-2/Upstream/104499; hsa-let-7a-1/Downstream/2035573;
Nearest TSS
ENST00000422679/Upstream/5331; ENST00000432139/Downstream/8174;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/47636, chr9-CpG: 37/Downstream/104353
Upstream sequence
cgcgggTCCCGCCCCGGCGGGCCGCTGGAAAAGTTTAGTCTCTGACTCGCTCGGGCAGAGGCCGAGGAAGCCGGTTCCGGGGACGGGCAACAGGGACTCA
Downstream sequence
TAGAATATTTTCATATCATATGATGTATATTTATATGTTATTTTAAATGATTTTTTTAGCCTCCTTAAGTTTTAAGTGGATCTTGCAAATGAACACCAGT
Target sequence
AAGATCATAAAACTTTATTACTGGGCTATTTACATGAAATTTTAATTGTTTCTCATAAAATATAAAACATCACAATCTTTACTAAAG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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