PARD6G _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017258
Fusion event
HBV-PARD6G integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2657
End
2738
Integrated sequence
CAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAAC
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
78001924/80244041 (Hg38)
End
78001996/80244113 (Hg38)
Location type
Intron
Target gene
PARD6G
miRNAs that regulate target gene
hsa-mir-4279 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6814-5p ; hsa-mir-4446-5p ; hsa-mir-223-5p ; hsa-mir-4524a-3p ; hsa-mir-4740-3p
Nearest miRNA
hsa-mir-1-2/Upstream/7390659;
Nearest TSS
ENST00000575820/Upstream/41160; ENST00000470488/Downstream/3235;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/83335, chr18-CpG: 189/Downstream/2032
Upstream sequence
gagaatgttcaattctgtgacttgaaggcagacatcacaaagcagtttctgagaatgcttctgtcgagattatatacgaagatactcccgtttccaacga
Downstream sequence
CCAGCACTGGCTTTTCCGCTGCATTCTAAGGTGGCCAAGGACTCTTGCTCTCCTCCACGTGAAACACCCTAACCCTCTGCGTAGCTCCTCCCTCCCCACG
Target sequence
GTGTTGCTTGCTGTCTTCTCCTCATATGAAAATTCATCTCCATTTACCGCCCCCTGTAAACCCCTTCCGATC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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