PIK3R5 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017261
Fusion event
HBV-PIK3R5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1379
End
1466
Integrated sequence
CTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTC
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
8794231/8890914 (Hg38)
End
8794305/8890988 (Hg38)
Location type
Intron
Target gene
PIK3R5
Nearest miRNA
hsa-mir-1253/Upstream/703910; hsa-mir-10226/Downstream/3190911;
Nearest TSS
ENST00000595228/Upstream/2401; ENST00000585297/Downstream/2662;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/2227, chr17-CpG: 81/Downstream/74164
Upstream sequence
tctcacatctgggtctgtttctatagattgagttttctcctggttataggtcaacttcatgtcatgcttggtaatttgtgattgacgtcagacattcttt
Downstream sequence
CTGGTGCTCAGCTCCACTGAGACCAGGGCCTCCTCAAGCCCAGGCAGAGCTCGAGGAGGTGACCACAGGAGGCCAGGACAGAAGCAACAGCTCCAGGGTC
Target sequence
GGGGACACAGGGGACCGGCTATGGCACCCAGGGGTGCGCAGCATGCCACAGTGCAGCCACCCCCCTCGTGCCTG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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