Basic Information
VIS ID
TVIS10017265
Fusion event
HBV-TRGC2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1646
End
1732
Integrated sequence
AGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACT
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
38279314/38239713 (Hg38)
End
38279370/38239769 (Hg38)
Location type
Intron
Target gene
TRGC2
Nearest miRNA
hsa-mir-1183/Upstream/1320281; hsa-mir-10399/Downstream/4911126;
Nearest TSS
ENST00000635602/Upstream/61318; ENST00000629576/Downstream/9803;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/61313, chr7-CpG: 38/Downstream/71550
Upstream sequence
tctaagtcctttaaaagcgtattttaattctcccccttgccaacaaccctttgatataataatcctcattttaaaacgggcagaaattgaagcttaggaa
Downstream sequence
TGGCTGGAGGAGCTGTGGAAAACATGGAGAGATTGGTGCTGGAGATCGCCATGGCTATTCCTCATTGTTATTACAGAGTGAGGTTCTCTGTGTGCCCACT
Target sequence
GAGGGACAAGGCTAGAAGCCGCAGGCTGTCTACACTATAGCAGGCGCTATTTGGGT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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