Basic Information
VIS ID
TVIS10017270
Fusion event
HBV-chr19 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
712
End
805
Integrated sequence
TTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACC
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
47370723/46867466 (Hg38)
End
47370826/46867569 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-mir-10395/Upstream/158112; hsa-let-7e/Downstream/359373;
Nearest TSS
ENST00000633603/Upstream/16474; ENST00000596593/Downstream/51107;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/5921, chr19-CpG: 40/Downstream/136480
Upstream sequence
TGCCGCTGTCTGGGGTAGAGGAGAAGATGTTCAGCCTCCTCAAGAGAGCCAAAGTGCAGCTATTCAAGATCGATCAGCAGCAGCAGCAGAAGGTGGCAGC
Downstream sequence
attctgccttattttgtggctaataatacttgattgtcatctctctctctagatagacagtaaactcctgaggatgaggagcctcttatattatctttga
Target sequence
agccctgtcatttactagctttgtgactagccaaatcattttcatttctctggactacagttccttcatttgaaaaatgaagggattatactagttggttccc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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