Basic Information
VIS ID
TVIS10017272
Fusion event
HBV-IGL integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1529
End
1616
Integrated sequence
ACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGAC
Host Sequence
Chromosome
chr22
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
22627200/22272818 (Hg38)
End
22627296/22272914 (Hg38)
Location type
Intronic
Target gene
IGL
Nearest miRNA
hsa-mir-1286/Upstream/619433; hsa-let-7a-3/Downstream/549862;
Nearest TSS
ENST00000624155/Upstream/8217; ENST00000412149/Downstream/14306;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/49299, chr22-CpG: 69/Downstream/235391
Upstream sequence
TGGCATTGTTAGTGCTTCTCTTTTAATACTGTAGAAATTAATCAATTTGGTGGCGTATTTAATTAATTCTATCACTAGAGGATTGTAAAATTACATATAT
Downstream sequence
CTAAATTATAAATCTAGAATTTAGAGAGTATATTTCCCCACTGGATTACATTTTTGGAATTATTATATGTGCACAAATATTACAAAATCACTGTAGACAC
Target sequence
GAATACCTCACTTTAGAGACCACTTAATTTTTTTTCCAAGGGGATATTTGACTATATTTCACTTGTGTCTTATTTAATGATTTTATAATTTAAACC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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