Basic Information
VIS ID
TVIS10017273
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1819
End
1910
Integrated sequence
AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC
Host Sequence
Chromosome
chr8
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
43827051/43971908 (Hg38)
End
43827148/43972005 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/1075633; hsa-mir-10400/Downstream/17742783;
Nearest TSS
ENST00000518652/Upstream/775740; ENST00000518278/Downstream/2850232;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/694573, chr8-CpG: 41/Downstream/2645362
Upstream sequence
ATTCCAGTTTCACAGTCTTTTTTTTTTTTTACCAAAAAACTGCATTTTTATTCCTGCACCTCAAATTCAACCACTGTAACCTCCAATCAGAATACCATTC
Downstream sequence
aggaaacactcattttgtagtatctggaagtggacatttggagcgctttcaggcctatggtgtaaaaggaaatatcttcccataaaagcgacatagaagc
Target sequence
tcttcaaagaaaatctagacagaagcattctcagaaacaccttcgtgatgtttgcaatcaagtcacagagttgaaccttccgtttcatagagcaggt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate