Fusion event
HBV-FAM157B integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
CATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGT
End
141114423/138223973 (Hg38)
Nearest miRNA
hsa-let-7a-1/Upstream/385360;
Upstream sequence
TCCAGTTAGCTGATCCAGCTTAAGGGGAACTGGGTCACCTGCATTGAAGGTCAGAGTGGCCGGTGAGACTTGAATAACAAGCCTGGTGGGGCATATTCCT
Downstream sequence
gatacattcccaagtcagatttacagtttgtttctatactaaattaggttgcgattcttcttgttcttcttcttttttcttttttgaggcggagtctcgc
Target sequence
atttgccttcttggaacttgttttgaacagctggctgccggccattgactgacactcggctgatgtgattggctgaaccgccgctatttgttaccat
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.