PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017275
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1293
End
1384
Integrated sequence
GTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTA
Host Sequence
Chromosome
chr12
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
24431316/24278382 (Hg38)
End
24431412/24278478 (Hg38)
Location type
Intron
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/65887; hsa-let-7i/Downstream/1595542;
Nearest TSS
ENST00000382841/Upstream/55095; ENST00000536131/Downstream/78952;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1653103, chr12-CpG: 92/Downstream/283544
Upstream sequence
ccataataggtttgcaagaacctgagcctatgaccctagcccaagacctactgcatctgaaatccagtgccactgaagctgcttgcagggccatcagtcc
Downstream sequence
gcagcaaaagtattacttgaacccaggagttcaagactagcatgggcaacactgagactccagctctacaaaaaatttaaaaattagctaagcatggtgg
Target sequence
AGAATATTCCACAAAGAGAAAAATTATCATTAAAAACTTTGAACATCAggctgggtatgatgactcacgcctgtaatcccagcactctgggaggct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate