PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017276
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
145
End
234
Integrated sequence
CTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCA
Host Sequence
Chromosome
chr12
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
24431417/24278483 (Hg38)
End
24431515/24278581 (Hg38)
Location type
Intron
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-1244-3/Upstream/65988; hsa-let-7i/Downstream/1595439;
Nearest TSS
ENST00000382841/Upstream/55196; ENST00000536131/Downstream/78849;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1653204, chr12-CpG: 92/Downstream/283441
Upstream sequence
ATGCTATACAAGTAAGAACATATAAACTCGTGTACACAGTCTCATGCCTTCCTGTGCCTCCAGCATCCCCTTCCTTCTCAGCTATCATTTACCCCACGTT
Downstream sequence
gcatctgtagtcccagctatttgggagaatgaggtgagaggactgcttgagtccaggaggttgagattgcagtaagctgtggttgcgtcactgcacttca
Target sequence
aaaagtattacttgaacccaggagttcaagactagcatgggcaacactgagactccagctctacaaaaaatttaaaaattagctaagcatggtggcat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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