Basic Information
VIS ID
TVIS10017277
Fusion event
HBV-LINC00448 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
164
End
252
Integrated sequence
CATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAG
Host Sequence
Chromosome
chr13
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
63341487/62767354 (Hg38)
End
63341524/62767391 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
LINC00448
Nearest miRNA
hsa-mir-1297/Upstream/1567474; hsa-mir-1267/Downstream/3198939;
Nearest TSS
ENST00000623511/Upstream/34995; ENST00000618134/Downstream/267601;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/2369443, chr13-CpG: 36/Downstream/1044195
Upstream sequence
tgcccaggctggagtccagtggtgctatcttggctcactgcaacctctgtcttccaggttcaagtgattctctcactgcagcctcccgagtagctgggat
Downstream sequence
GTTGTTACTAAGCATCTGTCTTTTTTTTGGGGAAACAACCCTAGTTCTTTGAAGAATTGCATATTCTTCTATCTAGAGCTGTGGTTTTCAGAGAGAAAAT
Target sequence
ATATTTGTTTGTTCTGTTTTTTTTTTTTTTTGCTGTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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