Basic Information
VIS ID
TVIS10017279
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2678
End
2770
Integrated sequence
CATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGG
Host Sequence
Chromosome
chr8
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
37068433/37210915 (Hg38)
End
37068534/37211016 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/7253567; hsa-mir-10400/Downstream/4060032;
Nearest TSS
ENST00000518652/Upstream/141497; ENST00000517897/Downstream/195708;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1974322, chr8-CpG: 351/Downstream/483410
Upstream sequence
tcttcatagaaaatttagacagaagcattctcagaaccttgattgtgatgtgtgttctccactaacagagttgaacctttcttttgacagaactgttttg
Downstream sequence
gctcaataaagtctgaattggataagctggaagagattcacacataggcatacgatagtcaaactgttctaagatagagacaaagagaggatctcgaaag
Target sequence
ggaaagagagagtcaaacaaacaaacaaacaaacaaaaaacagaagaaataatgcctaaaagcttacaaaatgtaatgaaaaccaatctacacattgagaa
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate