PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017283
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2085
End
2176
Integrated sequence
TGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAA
Host Sequence
Chromosome
chr10
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
81521897/79762141 (Hg38)
End
81521995/79762239 (Hg38)
Location type
Intron
Fragile sites / regions
FRA10D
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-1265/Upstream/4209588; hsa-mir-107/Downstream/6502455;
Nearest TSS
ENST00000439456/Upstream/55813; ENST00000605920/Downstream/4085;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/61154, chr10-CpG: 127/Downstream/63675
Upstream sequence
tcaaatgcaatcgaatggaattatAGAATGCCATCAAATAGaatcatcgaatggactcgaatggaatcatcgaatggaatggaatggaatagtcaatgaa
Downstream sequence
AGTATGTGAACTTTTTAGATTAAAAATTTCCAGCACAGATTTATCACTTATTATATCCTTTTATTCCTTGAAATGGATGATTGTCAGGTAGAAATTTAGG
Target sequence
AAAATTCAAAACCATTTAAAATATGTCGCCATTGATTTCCTTATTAATAGGTTTTAATACCTCCATCTTTCTCTAATAGTTTTCAGTTTATTAGAAAT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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