PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017284
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1737
End
1827
Integrated sequence
GGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
109784433/108024675 (Hg38)
End
109784532/108024774 (Hg38)
Location type
Intron
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-107/Upstream/3756270; hsa-mir-202/Downstream/2873316;
Nearest TSS
ENST00000439456/Upstream/860141; ENST00000421481/Downstream/15925;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/109469, chr10-CpG: 63/Downstream/441395
Upstream sequence
ttaggggttagggtcggggtcggggtcggggtcggggtcagggtcagggtcagggtgagggtgagggtgagggtgagggtcagggtgagggtgagggtga
Downstream sequence
tctcaataaaatactggcaaaccgaatccagcaccacatcaaaagccttatccactacaattaagttggcttcatccctgggaaacaagtctggttcaac
Target sequence
tttatgaggccagcatcatcctgataccaacacctggcagagacacacacaaaaaagaaaattttagtccaatattcctgtgaacatcgattcaaaaat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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