Basic Information
VIS ID
TVIS10017285
Fusion event
HBV-LOC105371002 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
612
End
701
Integrated sequence
CCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGG
Host Sequence
Chromosome
chr15
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
97235293/96692063 (Hg38)
End
97235391/96692161 (Hg38)
Location type
Intronic
Target gene
LOC105371002
Nearest miRNA
hsa-mir-10393/Upstream/358756; hsa-mir-1302-10/Downstream/2092265;
Nearest TSS
ENST00000557528/Upstream/243221; ENST00000561002/Downstream/89493;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/274762, chr15-CpG: 32/Downstream/960630
Upstream sequence
aattaaactaaagagcttctgcacagcaaaagaaactaccatcagagtgaacaggcaacctacagaatgggagaaaacttttgcagtctatccatctgac
Downstream sequence
CTGGAGAATGGATGGAGAAGTGGGGAGGTCTCTGAGATGTCTGTCTGGACAAAAGACATTGACTTCCTGAGCAAAGACCCCAGGAAGCCACATTTAAAGC
Target sequence
GGATTTTCTTATATCCTAAGAAGAGTGAACCAAGGTTCGGGAGTCAACAAGCAATTCAATAATTAAAGAATGAGGAGTGGTCCTGTTCAGAGACAGAG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate