Basic Information
VIS ID
TVIS10017286
Fusion event
HBV-chr17 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
728
End
809
Integrated sequence
GCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATT
Host Sequence
Chromosome
chr17
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
22245498/22746171 (Hg38)
End
22245596/22746269 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/3401597; hsa-mir-10226/Downstream/4547641;
Nearest TSS
ENST00000595228/Upstream/53337; ENST00000583786/Downstream/4253656;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/53489, chr17-CpG: 114/Downstream/3984759
Upstream sequence
ACTAATTTTTCATAACTCAGCAGTTCTCTGGGCTTCTAAATTTAACTTTTGCTCTTATATTTCTTCTCTTTTCTTTACCTCTATGAATTGCTGCCAAGTT
Downstream sequence
gaactttccttttgagagagaagctttgaaacactctttttctagaatctgcaagtggatatttggagggctttgaggcctgtggtggaaaaggaattat
Target sequence
tgaagatttcgttggaaacgggataatcttcacagaaaagctaaacagaagcattctcagaaacttctttgtgatgtttgctttcaactcacagagtt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate