Basic Information
VIS ID
TVIS10017287
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
826
End
916
Integrated sequence
TATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAA
Host Sequence
Chromosome
chr3
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
32943638/32902146 (Hg38)
End
32943733/32902241 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/395757; hsa-let-7g/Downstream/2842235;
Nearest TSS
ENST00000440867/Upstream/84128; ENST00000330953/Downstream/49333;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/80223, chr3-CpG: 67/Downstream/194350
Nearby gene
TRIM71(-4320) ;
Upstream sequence
atagagagaccaatgtgaccaaaacaaacaaactgtgaccaaaacaaacacctgagcgagtcctctggctaacagccggtgaaaaactgaaggctaccat
Downstream sequence
aaaaaaaaaaaaaaaaaaaaaaaaaaaaaGACTTTCATGTCTCCCAAGCAACAATCCaaatttttaaaatttaattaatGAGGACTAGAATAAAACACTG
Target sequence
gcaggagaattgcttgaatctgcaaggcggaggttgcagtgagcctagatggcgccactggactccagcctgggtgacagtgagacaacgtctga
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate