Basic Information
VIS ID
TVIS10017288
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1748
End
1836
Integrated sequence
AGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCC
Host Sequence
Chromosome
chr3
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
32957535/32916043 (Hg38)
End
32957621/32916129 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/409654; hsa-let-7g/Downstream/2828347;
Nearest TSS
ENST00000440867/Upstream/98025; ENST00000330953/Downstream/35445;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/94120, chr3-CpG: 67/Downstream/180462
Upstream sequence
CCCAGCCCGTCACAGTGCAGCGGGAATGGTCCTTCAACACATAGTCCGTGCCAGGCAGGCAGATGGGCCGCACGTAATTGCTGTACTTGAGTTCCTGCTT
Downstream sequence
ctcgtgatccaccccttttggcctcccaaagtgctgggattacaggcgtgagccaccgcgcccggccTTAAAAGTGTTTTTATCAGGAAGTGTTCCCAGA
Target sequence
ccgccaccatgcccagataattttcttgtatttttagtagagacagagtttcaccatgttggccaggctggtctcgaactcctgac
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate