hsa-mir-4744 _LIHC.png
VGLL3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017289
Fusion event
HBV-VGLL3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2528
End
2605
Integrated sequence
GGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCA
Host Sequence
Chromosome
chr3
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
86998358/86949208 (Hg38)
End
86998448/86949298 (Hg38)
Location type
Intron
Target gene
VGLL3
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-mir-24-3p ; hsa-mir-6720-5p ; hsa-mir-7703 ; hsa-mir-6512-3p ; hsa-mir-4252 ; hsa-mir-766-3p ; hsa-mir-1292-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-4293 ; hsa-mir-508-5p ; hsa-mir-1324 ; hsa-mir-224-5p ; hsa-mir-4509 ; hsa-mir-4744 ; hsa-mir-6782-3p
Nearest miRNA
hsa-let-7g/Upstream/1563416; hsa-mir-12124/Downstream/276891;
Nearest TSS
ENST00000440867/Upstream/467265; ENST00000629295/Downstream/19333;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1989522, chr3-CpG: 78/Downstream/41162
Upstream sequence
CCCAGGACCAGAACCGCTGGGCCCGGTACCTGCTATGCATGATGACCTGGAGCACCGGGACATCGGAGGCGGTCTGCGTCATCTGGTCAATCCACGGACT
Downstream sequence
TCCATGTCTCTGCATTTCTACAATGCGAATCTTAAAAAGTCAATTCCTCTGTGGCCTAAAATGTATCAGATATCTAATGGACCCTTGTGGTTAAACTTCT
Target sequence
TATTTCATTACTTAAGATCGCCCCAGATTTTCCAATCAGAATAACAGAAGTCATTCTCTCGTTATAAATTCATATATTCAATTTCTTGTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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