Basic Information
VIS ID
TVIS10017290
Fusion event
HBV-LOC101928856 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1116
End
1206
Integrated sequence
CCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGG
Host Sequence
Chromosome
chr3
Cytoband
q26.33
Reference genome
GRCh37/hg19
Start
180293326/180575538 (Hg38)
End
180293425/180575637 (Hg38)
Location type
Intronic
Target gene
LOC101928856
Nearest miRNA
hsa-let-7g/Upstream/4060387; hsa-mir-1224/Downstream/3311163;
Nearest TSS
ENST00000440867/Upstream/161326; ENST00000491380/Downstream/26298;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/538081, chr3-CpG: 55/Downstream/26398
Upstream sequence
TTATAACATGTACCCAGGGATGAACCATTGATTTATAACATGTAAAACATAACTATTTTCTTCCAATTTTTTCCACATCCtatataatattcatttttta
Downstream sequence
GGAGAAAGGCTTCCGTGGAAAACGTCAGGACCACTGATCTGTACTCAACAGCTCCAGATACAGATTTGATCTAATTAACCTCAGTATTTCTATCACTTAA
Target sequence
CTGTGTGTTTTGTTTTTACAGACATGCATGTACAAACAGGAGCTGCAGGGGTAATGGTGCAGATCTTCGTGTCTTAAAATCTGGGCCTACTGTGAGATA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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