Basic Information
VIS ID
TVIS10017291
Fusion event
HBV-chrX integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1399
End
1487
Integrated sequence
CTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTC
Host Sequence
Chromosome
chrX
Cytoband
q27.3
Reference genome
GRCh37/hg19
Start
146427592/147346074 (Hg38)
End
146427660/147346142 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRAXE ; FRAXF
Nearest miRNA
hsa-let-7f-2/Upstream/61346; hsa-mir-105-1/Downstream/2881862;
Nearest TSS
ENST00000429181/Upstream/165010; ENST00000621447/Downstream/555317;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/725311, chrX-CpG: 91/Downstream/565431
Upstream sequence
ATTTCTGGAAGTGAATTACTGGTAATAATGAATAAAGAAGTTTCTTTTAAAGAAGGGGTTCTTTAGCACAAAAGGAATGCTTCCCTCCAGAGCAGACAGG
Downstream sequence
AAAACTTttaaactatctgcacgttactttatctctaaaagggggttactatatgtctgacctatctcccaaagttattatgagaaccaaaaggatatca
Target sequence
tcaaaaaaTAATAATAATaataaataaataaataaataaataaataaaaataaataaGGATAAAAATT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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