Basic Information
VIS ID
TVIS10017293
Fusion event
HBV-chr6 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2739
End
2826
Integrated sequence
TAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATAT
Host Sequence
Chromosome
chr6
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
58778406/58452128 (Hg38)
End
58778493/58452215 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/1061916; hsa-mir-10524/Downstream/12924745;
Nearest TSS
ENST00000381078/Upstream/413662; ENST00000622616/Downstream/2270933;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/490578, chr6-CpG: 45/Downstream/3833735
Upstream sequence
gcaggagaatcgcttgaacccgggaggtggaggttgcagtgagccgagatcgcgccactgcactccaacctgggcgacagagcaagactccgtcctccgt
Downstream sequence
gtgcattcaactcaccgagtgcaacattcctcttgatagagcagtttggaaacattgtttctgtagaatctgcaagtggatatttggacctctttgaggc
Target sequence
gagagtgctttcaggcctatggtagaaaagggaatatctttccataaaaggtagacagaagcaatctcagaaactgctttgtgatgt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate