Basic Information
VIS ID
TVIS10017297
Fusion event
HBV-CTD integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2505
End
2596
Integrated sequence
TGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAG
Host Sequence
Chromosome
chr15
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
81731997/81439656 (Hg38)
End
81732097/81439756 (Hg38)
Location type
Intron
Target gene
CTD
Nearest miRNA
hsa-mir-10393/Upstream/442183; hsa-mir-11181/Downstream/1627579;
Nearest TSS
ENST00000557528/Upstream/12208; ENST00000558153/Downstream/114247;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/115034, chr15-CpG: 383/Downstream/603375
Upstream sequence
GCCTTTTCTCCTTTCCAAGTGAAAACCTCACAGATCAGTATATTTATAGGAAGACCTTATTATGTAATTTAATAATAATTCCTACTTGGATCctctgtgg
Downstream sequence
TGCCTTTCTGAAATTTGTAGACTTTCTCTTGTATGGGATTACAGCATTCTCTTTTCCaaaataatttttttctgtttttaaaattaatacatttttattG
Target sequence
ATATCATGTTTAACATGGGCGTGTATCCCATTTTCGTCTCAAATAAGCAGCTAATTACAAGCATATTCACTCAAAGAAGAACTGATTTTCAATTTAGACC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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