Basic Information
VIS ID
TVIS10017301
Fusion event
HBV-chr18 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1739
End
1826
Integrated sequence
AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
535047/535047 (Hg38)
End
535140/535140 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-8078/Upstream/422708; hsa-mir-1-2/Downstream/3350213;
Nearest TSS
ENST00000575820/Upstream/19753; ENST00000327228/Downstream/45217;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/19570, chr18-CpG: 56/Downstream/45039
Upstream sequence
TGAGCTGTGTTTCTCTGGATTTTTCAAGCTCATGCGGACGACAGTGGAATTGACGCAATACTGACGTAGGTAAAGGCGTTGCTAAGTTCGTAGTGGCACC
Downstream sequence
cgtagctaggactacatgcatgtgccaccactcccggctaatttttattttcatttttagtttttgtagagatagggtctcactatgttgcccaggttgA
Target sequence
tctgtcgccaaggctggagtgcagtggtgccttcatggctcattgcagcctcgacctcccaagctcaagcaatcctcccgcctcagcctcctg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate