Fusion event
HBV-CCNE1 integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
TTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCA
End
30303231/29812324 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10395/Upstream/9412873; hsa-let-7e/Downstream/5310376;
Nearest cancer related gene
Upstream sequence
CACCTCTCCTCCCACTCCAACCCCCAGCACCGCCACGGGAGGCCCTCCGGAAGACAGTCCCACCGTGGCCCCCAAAAGCACCACCTTCCTGAAGAATATC
Downstream sequence
cgggccccgggaggcgacgggccggtgagggcggcgggggcggcgggaccccgggtcgggggtcggcgggtgcccgggTCGCGGGTGACAGGCCACCCCG
Target sequence
gtgcggccgggtcgcgggtccccgggcggcgtcgcggggcgcccgggAGGGTGCTGAGAGCGCGGCGGGGTGGGGTGGAGGGGACACTGAGGCAgcc
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.