Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017303
Fusion event
HBV-CCNE1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Start
3009
End
3101
Integrated sequence
TGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCT
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
Start
End
30303424/29812517 (Hg38)
Location type
Promoter
Target gene
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b
Nearest miRNA
hsa-mir-10395/Upstream/9413062; hsa-let-7e/Downstream/5310183;
Nearest CpG islands
chr19-CpG: 137/Target, None/Upstream, None/Downstream
Nearest cancer related gene
CCNE1(OG, No orient, 0)
Upstream sequence
GCTACTGCAGCCCCTGCAGGCCTTGCAAACCCAGCTCCTGCCCCAGGCACTACCGCCACCACAGCCACAGCTGCAGCCACCGCCGTCACCACAGCAGATG
Downstream sequence
GCGCCGCCCCGCAGGCCTCAGGCCGGAGCAGCCCCATCATGCCGAGGGAGCGCAGGGAGCGGTGAGTGCCCGCGCCGcggggccggacgggacgggacgg
Target sequence
CCACCCCGCCATCGGCCATCTTCCTGGCTCGCCCGGCCGCCCGCGCGCAAAGGGGGAAGGGGTACTGGGCCCGCGGCCTGACCCCGCCGCCGCCTCACCCC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.