Basic Information
VIS ID
TVIS10017306
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
562
End
653
Integrated sequence
CCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCC
Host Sequence
Chromosome
chr5
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
27432713/27432606 (Hg38)
End
27432808/27432701 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/10276614; hsa-mir-103a-1/Downstream/4503401;
Nearest TSS
ENST00000502646/Upstream/311456; ENST00000514255/Downstream/3710;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/762811, chr5-CpG: 76/Downstream/1376592
Upstream sequence
TGTCGTGGATCAGCTGGGCCTGGCGGGCCCGGGACTTGGTGAGACCAGCCGGTCTCAAAACTCCTCTGGGCGAGAGCGACCCGGGATGCCAGGCCGGAGG
Downstream sequence
TTTCCCAGTGGCATTCCAGCCAGTCTCTTTATTGCAACAAACTTACCCACCTGCTTTTCCACGTTTTTGGTGCAATTCCAATTATATAGCTACCTCTTTT
Target sequence
CATTTCATCTATCTCATCCAATTTCTGTTTCTGGGAGATGATCAGCCAGTTTGCCAGTCTCACTTACGATAATTACGTTTCCCTCTATCCAATTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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