Basic Information
VIS ID
TVIS10017307
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
466
End
558
Integrated sequence
TGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATC
Host Sequence
Chromosome
chr5
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
27434883/27434776 (Hg38)
End
27434982/27434875 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/10278784; hsa-mir-103a-1/Downstream/4501227;
Nearest TSS
ENST00000502646/Upstream/313626; ENST00000514255/Downstream/1536;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/764981, chr5-CpG: 76/Downstream/1374418
Upstream sequence
AGAGGTCGAATCGGCCTAGGCTGTGGGGTAACCCGAGGGAGGGGCCATGATGTGGAGGCCCTGGGAACAGGTGCGTGCGGCGACCCTTTGGCCGCTGGCC
Downstream sequence
AAAAAATCCTCTTCAACCAAGCTTTTGTATGTCTGTATTCCCTCCAGCCCTGACATTTAACACAGACTGTGGCATGAATAGTAGTTAAATACTCTGCTTC
Target sequence
CCGAATTCTCACCCATAACCATGATTACCTATTTCTGAAAGTGATCTGCAGAAGAAGAAATATAAGCACGTAAAATACAGCAAATTAAATTACATACGA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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