PPP3CC _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017309
Fusion event
HBV-PPP3CC integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1819
End
1909
Integrated sequence
AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACAT
Host Sequence
Chromosome
chr8
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
22350344/22492831 (Hg38)
End
22350437/22492924 (Hg38)
Location type
Intron
Target gene
PPP3CC
miRNAs that regulate target gene
hsa-mir-6086 ; hsa-mir-6851-3p ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-6832-3p ; hsa-mir-3922-5p
Nearest miRNA
hsa-mir-124-1/Upstream/247794; hsa-mir-10400/Downstream/2460872;
Nearest TSS
ENST00000518652/Upstream/17239; ENST00000523620/Downstream/5075;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/51202, chr8-CpG: 107/Downstream/58235
Nearest cancer related gene
PPP3CC(TSG, No orient, 0)
Upstream sequence
TGAAATTGGAACGGGAAACGTATGACAAAAATGCAAAGGTAATGCTGAAAATTAGGAGAAGAAAAAGCAGCATGAAGAAGGCACAAGTGAAAACTCTTAA
Downstream sequence
ACCAGCTTGGTGCACACTGTCTGACTAGTTTAAGGAGACTGGCTGAAGCTCTGCCCAAACAGTCTGTGAATGGAAAAGCACCACTTGCTACTGGAGAGGA
Target sequence
CCACTTTAACAGCAGAGATGCCAGCAAACTCTTTCACCATTACAGGCCATGCTGAGACAAAGCAGCTGATGGAAATGCTACCCAGCATCTTAA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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