Basic Information
VIS ID
TVIS10017310
Fusion event
HBV-CICP20 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1819
End
1910
Integrated sequence
AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC
Host Sequence
Chromosome
chr7
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
45855545/45815946 (Hg38)
End
45855639/45816040 (Hg38)
Location type
Intronic
Target gene
CICP20
Nearest miRNA
hsa-mir-1183/Upstream/934146; hsa-mir-10399/Downstream/11139745;
Nearest TSS
ENST00000635602/Upstream/131561; ENST00000457280/Downstream/57042;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/46800, chr7-CpG: 74/Downstream/72363
Upstream sequence
CAGCCATCTGTCAGCAAAACAGGAAGGCTCGGGCTGTCTCCTGGGCTCGTTTTGCTGCCGTAGTGAGCGTCACTTCTCCCCGTGTAAGAGTGCTGGTGAA
Downstream sequence
gagcaagactccgtctcaaaagaaaGAGGCAGGCCTTATTCTGTCCCAGACTGAAAGGATTAAATGGCTTTACCCAGGAGAAGATAACCATCCTGCCCTC
Target sequence
atcccagctacccggaaggctgaggcaggagaacccagcaggaagaggttgcagtgagccaagatcgcatcactgcactccagcctgggcgaca
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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