Basic Information
VIS ID
TVIS10017312
Fusion event
HBV-LOC100421031 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1595
End
1685
Integrated sequence
CCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTC
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
30351918/30340597 (Hg38)
End
30352014/30340693 (Hg38)
Location type
Intronic
Target gene
LOC100421031
Nearest miRNA
hsa-mir-1225/Upstream/741332; hsa-mir-11401/Downstream/163226;
Nearest TSS
ENST00000527434/Upstream/86087; ENST00000563252/Downstream/14241;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/5053, chr16-CpG: 52/Downstream/14192
Upstream sequence
ttccatttgagtccattcgatgatgattccattccattccattcgatgattccgtttgattccatttgatgattcccttcgattcctttctttgatgatt
Downstream sequence
ATTCAGCATCCAGGTGGCGTCGCCTCCGTGCAGGTGGCAATGAGCCCATCCTTTTGTTGAGTGACACACGCTGAGTTCAACGCGGGTGTTTCATTGTTGG
Target sequence
TAACATTTGTATTACCTCCCATCGGAGCCCTACTGGAATTAGCACAGAACCCACGTTGCTGTGCACCAGGGTCGGCTGTGTGGAGATTGGAAGCCT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate