Basic Information
VIS ID
TVIS10017317
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1826
End
1914
Integrated sequence
TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
86214426/86918609 (Hg38)
End
86214518/86918701 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/4078385; hsa-mir-103a-1/Downstream/196178;
Nearest TSS
ENST00000502646/Upstream/120924; ENST00000515750/Downstream/48620;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2533824, chr5-CpG: 34/Downstream/348839
Upstream sequence
CCACAGATCCCCACCTACCCCACGGATGAAAACCAATTCACAGATCCCCACCTACCCCACACATAAAAACCAATCCCACAGGTCCCCACCTACCCCACAC
Downstream sequence
atatataatatatatatatactatagagcatgtataatatatatactatatttactttatgttatatatactatatttacttatatatttagtatatatg
Target sequence
GGGTCATAAGAGGAAAGATATATAGTAATATTCTGGTAGTGTTTATCTCTGGTGAGATCATATCTTAACCTATATTTGTGTGTATTTtatat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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