Basic Information
VIS ID
TVIS10017319
Fusion event
HBV-chr10 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2077
End
2166
Integrated sequence
TTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATG
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
42385987/41854123 (Hg38)
End
42386085/41854221 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/6212871; hsa-mir-107/Downstream/1143342;
Nearest TSS
ENST00000439456/Upstream/3400942; ENST00000442306/Downstream/331118;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2911017, chr10-CpG: 184/Downstream/256812
Upstream sequence
attgcattccattgcattccattcctttcctttccattccattcctttccagtccattgcattccattccaatccattccattccattccactcttgttt
Downstream sequence
aatggaatcatcgtcgaacggaaacaaatggaatcatcatcgaatgcaaatgaaaggagtcatcatctaatggaatcgcatggaatcatcatcaaatgga
Target sequence
gaatggaataatccatggactcgaatgcaatcatcatcgaatagaatcgaatggaatcatcgaatggactcgaatggaataatcattgaacggaatcg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate