Basic Information
VIS ID
TVIS10017322
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1732
End
1823
Integrated sequence
TGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
153509605/152588453 (Hg38)
End
153509705/152588553 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/51937; hsa-mir-1305/Downstream/6540249;
Nearest TSS
ENST00000502981/Upstream/52390; ENST00000515789/Downstream/52872;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/51762, chr4-CpG: 71/Downstream/190834
Upstream sequence
GTTTTATCAGCATTTTGtgtgttttatggaattccctccatgttaacatgtataaatcaactcattctttatagtagctgtataatattccaagatatgg
Downstream sequence
GACATTTCTCTACTTCCATCCCTTCTCCCAATCCCCCTTACTTATCTATCATTCCAATGCCTTCCAGGCCAAGTCAAATCCTGATTTCCCCAAGAAACAT
Target sequence
TAACTCTGCCTGGAGAAGCTCTCCATGGGCGGGACCCATAAGCTCACCTGGGCTGGGGCCTCTTTCCAAGAAAGCCTCTGTCAGCTTGCAAAGGATCTAA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate