Basic Information
VIS ID
TVIS10017323
Fusion event
HBV-chr1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2810
End
2899
Integrated sequence
TTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCAC
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
20433377/20106884 (Hg38)
End
20433475/20106982 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-12136/Upstream/1209736; hsa-mir-101-1/Downstream/526697;
Nearest TSS
ENST00000473358/Upstream/36589; ENST00000465062/Downstream/12575;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/223915, chr1-CpG: 36/Downstream/78885
Nearby gene
PLA2G2D(+5766) ;
Upstream sequence
gccggcgtgcgtctatgccctgcgccgcgtctccccaacagcgccgcgcgcgcctctctgcgcctgcgccggcgcgccgcgcctctctgcgcctgcgccg
Downstream sequence
GACACCAagtcttgctctgttactcaggctggagtgcgatcttggctcactgcaacctttgcctccctggttcaagcaattctcctgtctcagcctccca
Target sequence
GGGGTGGCGAGGGTCGCACCAGGACCCTGGGCTTAACATGGCTTTTGCTCACTTTTGCCCAGCTTCCACCATTTCTTTCTGGGGGCAGGGGGTGGGGG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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