Basic Information
VIS ID
TVIS10017324
Fusion event
HBV-chr1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1
End
76
Integrated sequence
ATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTC
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
20433478/20106985 (Hg38)
End
20433578/20107085 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-12136/Upstream/1209837; hsa-mir-101-1/Downstream/526594;
Nearest TSS
ENST00000473358/Upstream/36690; ENST00000465062/Downstream/12472;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/224016, chr1-CpG: 36/Downstream/78782
Nearby gene
PLA2G2D(+5665) ;
Upstream sequence
TTCCTTCCTGCTGGTTTTCCAAGCAGGAAGGCTACGGTGGTTtgtgtgtttgtgtgtgtatgtgcatgggtgtggtgtgtatgtgtacatgggtgtgtgc
Downstream sequence
agctgggattacaggcatatgccaccaagcccagctaatttttgtatttttagtagagatcgggtttcaccatgttggtcaggctggtcttgaactcctg
Target sequence
ACCAagtcttgctctgttactcaggctggagtgcgatcttggctcactgcaacctttgcctccctggttcaagcaattctcctgtctcagcctcccaagt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate