Basic Information
VIS ID
TVIS10017334
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1093
End
1182
Integrated sequence
CACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGT
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
709736/709621 (Hg38)
End
709829/709714 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Downstream/353182;
Nearest TSS
ENST00000502646/Upstream/16226; ENST00000508456/Downstream/22957;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/15359, chr5-CpG: 24/Downstream/41162
Nearby gene
TPPP(-8894) ; ZDHHC11B(+734) ;
Upstream sequence
GTAGAAGCCACACGGCCACTGGTCCCCTCCAGACCTGGGGCCCCGGCACAACCGCAGGACAGCTGAGGACTTCCCAGGAATCCAGACTCCGGGTTGCTCA
Downstream sequence
attgtatccattgtatctgggaagtaaatcacttgtttctgatctcacaggctcataggtgaaaggaattcatctccagatgagactttggacttggcat
Target sequence
tgagtttcagacttgcttggagcctgtagcctctttcttttggccaatttcttccttttggaataagtatgtttacccagtgcctgtaccatc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate