Basic Information
VIS ID
TVIS10017335
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2247
End
2337
Integrated sequence
ATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGA
Host Sequence
Chromosome
chr8
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
43831540/43976397 (Hg38)
End
43831639/43976496 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/1080122; hsa-mir-10400/Downstream/17738292;
Nearest TSS
ENST00000518652/Upstream/780229; ENST00000518278/Downstream/2845741;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/699062, chr8-CpG: 41/Downstream/2640871
Upstream sequence
TCACACATTCTCAACGGCTTGTAGCAAGAGTGACAAATGCCACTTATTCTCTCGCTTCGGAGTATCACACAATGTTTTGCCTTACAAAGTCCAAGACAAA
Downstream sequence
atgaatgcgagatagaagtaatctcagaaacatgtttatgctgtatctactcaactaagtgtgctgaacatttctattaatagagcagttttgagacact
Target sequence
ccctcacatagagcagttgtgcagcactctatttgtagtatctggaagtggacatttggagggctttgtagcctatctggaaaaaggaaatatcttccc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate