Basic Information
VIS ID
TVIS10017336
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1415
End
1507
Integrated sequence
ACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCG
Host Sequence
Chromosome
chr8
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
46843668/45932046 (Hg38)
End
46843769/45932147 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/3035771; hsa-mir-10400/Downstream/15782641;
Nearest TSS
ENST00000518652/Upstream/2735878; ENST00000518278/Downstream/890090;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/2654711, chr8-CpG: 41/Downstream/685220
Upstream sequence
GCTTGTGAATTTTTCTTAAAAATAAAACTCCAACTCTATTAATCCATGCCAGTTAAACACTATAACTAAAATTTCCAAATAAGCGCAAAAGGAGATGAAG
Downstream sequence
gtgcagcactctatttgtagtatctcgaagtggacatttggagggctttgtagcctatctggaaaaaggaaatatcttccgatgaatgcgagatagaagt
Target sequence
cgggcttacatgtaaaaattagacagcagcattctcagaaacttctttgtggtgtctgcgttcaagtcacagaattgaacatcccctcacatagagcagtt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate