Fusion event
HBV-chr6 integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTT
End
139027412/138706275 (Hg38)
Nearest miRNA
hsa-mir-10398/Upstream/270888; hsa-mir-1202/Downstream/1498977;
Upstream sequence
caccacagccacgagtgccgctcctgcGCCGCCCGCGGGCCTTAAGAAAGCGCGGGGAGCAGGGCCGCGACCCCAGCTGCGCCGCAAGGGCACCGccgcc
Downstream sequence
tattccatggtatatatgtgccacattttcttaatccagtctatcattgatggacatttgggttggttccaagtctttgctattgtgaatagtgctgcaa
Target sequence
tgtccttgtgatagtttgctgagaatgatggtttccagattcatccatgtccctgcaaaggacattaactcatccttttttatggctgcatac
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.