Basic Information
VIS ID
TVIS10017338
Fusion event
HBV-chr6 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2654
End
2749
Integrated sequence
ATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATT
Host Sequence
Chromosome
chr6
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
139027468/138706331 (Hg38)
End
139027564/138706427 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/271037; hsa-mir-1202/Downstream/1498825;
Nearest TSS
ENST00000381078/Upstream/9963; ENST00000617445/Downstream/66987;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/12587, chr6-CpG: 35/Downstream/66885
Nearby gene
FLJ46906(-9043) ;
Upstream sequence
TTTTACAAGTTGCACTTTAGAGTCAAATACATTTGAATTTAGTGGAAGCCATTCAAGGAGCTATCAAAGAAAATACAGAGCAGGAGAAAATTAAAGAAAT
Downstream sequence
gtatatacccagtaatgagatcactgggtcaaatggtaattctagttctagatccttgaggaatcaccacactgtcttccacaatggttgaactaattta
Target sequence
tttgggttggttccaagtctttgctattgtgaatagtgctgcaataaacatatgtatccatgtgtctttatggtagcatgatttataatcctttgg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate