Basic Information
VIS ID
TVIS10017339
Fusion event
HBV-LOC101927844 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
795
End
885
Integrated sequence
CCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTA
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
87682833/87217150 (Hg38)
End
87682932/87217249 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
LOC101927844
Nearest miRNA
hsa-mir-101-1/Upstream/859463; hsa-mir-11399/Downstream/6629583;
Nearest TSS
ENST00000473358/Upstream/4445; ENST00000640794/Downstream/3848;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/64847, chr1-CpG: 118/Downstream/110870
Upstream sequence
ACCGCAACTGAATGAATCTGCAATTTCTCTCAATTGTCCCTTATCCCTAAGCTGAAGGAAGTCAGCCTAGGCCCCCCAGATAGTGAGAGAGGTAGAATCC
Downstream sequence
TAACAGGCAAATATCTAAAAGCTTTCTTTAACAAGGTTTATTTCCATGTGAGAGAGCTGTGGGTTACACTGATGATGCAGGAGCTTAAGGAAGTGAGTAT
Target sequence
TGATCAGTTCAATAAATCCTTTGTTGTCTGTATAAAGTCTAGAGTTAAACAAACAACACAGAGCACAATATCGAGGTTTTGTCAAGTTTCTGGTGAACA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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