Basic Information
VIS ID
TVIS10017340
Fusion event
HBV-chr13 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1755
End
1842
Integrated sequence
TAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCA
Host Sequence
Chromosome
chr13
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
34654944/34080807 (Hg38)
End
34655041/34080904 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA13A
Nearest miRNA
hsa-mir-2276/Upstream/9918303; hsa-mir-1267/Downstream/5583130;
Nearest TSS
ENST00000623511/Upstream/250055; ENST00000605909/Downstream/267139;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/262451, chr13-CpG: 79/Downstream/861330
Nearby gene
VDAC1P12(+1970) ;
Upstream sequence
ctttaagtaaaaatgtatattgtaaaacctagtggaaaccattacaaTTTAAAAATGGGATAGTGAGTTGGTTGAGTAAATAAAATGCAATCATATCAAA
Downstream sequence
aattttgaataataaagatatatttgggaaagacacatttgcctgaaaataccttaaacaatgctaattttgaaaattttttaaggtcagctgataaaat
Target sequence
tgactataaggtgagtttatcattttttcttaaacaattatcacttagagaagagggactttgatattacatggtatgggctttattattaatactt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate