Basic Information
VIS ID
TVIS10017342
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1633
End
1685
Integrated sequence
CAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTC
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
58808766/57942600 (Hg38)
End
58808850/57942684 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA4B
Nearest miRNA
hsa-mir-12113/Upstream/5229853; hsa-mir-1243/Downstream/2979935;
Nearest TSS
ENST00000502981/Upstream/222565; ENST00000513836/Downstream/593644;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/746651, chr4-CpG: 222/Downstream/3257481
Upstream sequence
GTTTGCTTTCCAAGGAGGAACGGTGACATGCTCATCATTTACAGGAAGATCCTTAAGGGGTGCAACCTAAAAAAAAATTAATAACTGGCTTTGAGCCTAC
Downstream sequence
cgtgacggtgtgcacctgtaatcccagctactcggaaagctgagacaggagaatcgcttgaacctgggaggcgagattgcagtgagctgaagattgcacc
Target sequence
gcctgagctctcaggagttcgagaccagcctggggaatacggtgaaaccccgtctctactaaaaatacaaaaatgtttgccggg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate