Basic Information
VIS ID
TVIS10017343
Fusion event
HBV-chr17 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1712
End
1801
Integrated sequence
AAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT
Host Sequence
Chromosome
chr17
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
22249926/22750599 (Hg38)
End
22250024/22750697 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/3406025; hsa-mir-10226/Downstream/4543213;
Nearest TSS
ENST00000595228/Upstream/57765; ENST00000583786/Downstream/4249228;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/57917, chr17-CpG: 114/Downstream/3980331
Upstream sequence
tgtacatctgctaagaataaagacattcgcttacatcatcacaCCAAGAAAATTGGTAAGCTCCAGAATATTCAATATCCAATTCGTAGTTAGATTTCTT
Downstream sequence
tcatagagcagatgagaaacacgcttttcgtagggtctgcaagtggacatttggagagatttcaggcctgtggtggaaaacgaattatcgtcacgtaaaa
Target sequence
tggaaacgggaatatcttcacataaaaactaaacagaagcattctcagaaacttctctgtgatgtttgtgttcaactcacagagtttcacgttgcttt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate