Basic Information
VIS ID
TVIS10017345
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
413
End
500
Integrated sequence
CCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACA
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
58083241/57217075 (Hg38)
End
58083337/57217171 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA4B
Nearest miRNA
hsa-mir-12113/Upstream/4504328; hsa-mir-1243/Downstream/3705448;
Nearest TSS
ENST00000502981/Upstream/37930; ENST00000510956/Downstream/208701;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/21126, chr4-CpG: 222/Downstream/3982994
Upstream sequence
ACATAAGACATCTTAAAATGCAAATCATTAATATCATCTAATAATTATAATTACCGTAATTCCACACAGATTTTCCTTAAAACTTACCAAAACTACCATC
Downstream sequence
tgtgcttgtgccactgccctttagcctgggctacagagctagaccctatttcaaaacaaacaaacaaacaaacaaacaaacaaGAAAGGGGGCAGGTTGA
Target sequence
aaaattagttaggtgtattagtgcttgcctgtggtcccggatacttgggaaagtggaaagattgcttgagcctgggagtttgaggccacagtaagc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate