Basic Information
VIS ID
TVIS10017346
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1613
End
1701
Integrated sequence
AGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAG
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
58087958/57221792 (Hg38)
End
58088059/57221893 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA4B
Nearest miRNA
hsa-mir-12113/Upstream/4509045; hsa-mir-1243/Downstream/3700726;
Nearest TSS
ENST00000502981/Upstream/42647; ENST00000510956/Downstream/203979;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/25843, chr4-CpG: 222/Downstream/3978272
Upstream sequence
AGCTAAAAATGACTGCCATGGAAGGAATCTCATATTAACAAAGCACTTATTTCTTCAAACTAAAAAGAGCTTCTCATGACAAAATATGTAGAATATTTTA
Downstream sequence
gggctcaagggatcctcccactactgcctcccaagtagctgggagtacaggcatgcaccactatacctgacttatcttttaaaacacttttttttttttt
Target sequence
ACAGATCTTAATAGGTGGCTAGATGTGCCTGACCTTCTTTGACTGCAATccaggctggagtgcagtggcgtgatcataactcactgcagcatccaactcct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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